Can Sleep Apnea Drive High Blood Pressure?
A link between sleep apnea and blood pressure?
With obstructive sleep apnea, the upper throat closes and patients stop breathing numerous times during the night, putting them at risk for developing vascular disease that causes a treatment-resistant form of high blood pressure.
Nancy Kanagy, PhD, a professor in the University of New Mexico (UNM) Department of Cell Biology and Physiology, is seeking to understand how that happens.
Just how sleep apnea worsens blood pressure is not well understood, but up to one in five people may suffer from it. When the National Institutes of Health put out a call for proposals on sleep apnea research several years ago, Kanagy realized UNM’s experience in conducting vascular studies could provide a novel approach.
“Most researchers were looking at the sympathetic nervous system,” Kanagy says in a release. “We thought, ‘Why not develop a model to investigate vascular changes and contributions to the elevated blood pressure?’”
Kanagy’s team first developed a rat model of sleep apnea and found that it only takes about 14 days for repeated exposure to hypoxia during sleep to increase blood pressure, even during waking hours. They found that hypoxia increases production of an artery-constricting peptide called endothelin, which elevates blood pressure. Ongoing studies are investigating exactly how that happens.
Just how sleep apnea worsens blood pressure is not well understood, but up to one in five people may suffer from it. When the National Institutes of Health put out a call for proposals on sleep apnea research several years ago, Kanagy realized UNM’s experience in conducting vascular studies could provide a novel approach.
To view the rest of this sleep apnea related article, click below:
http://www.sleepreviewmag.com/2015/12/researcher-explores-sleep-apnea-drives-high-blood-pressure/
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